High resolution modelling of aerosol dispersion regimes during the CAPITOUL field experiment: from regional to local scale interactions

High resolution simulation of complex aerosol particle evolution and gaseous chemistry over an atmospheric urban area is of great interest for understanding air quality and processes. In this context, the CAPITOUL (Canopy and Aerosol Particle Interactions in the Toulouse Urban Layer) field experiment aims at a better understanding of the interactions between the urban dynamics and the aerosol plumes. During a two-day Intensive Observational Period, a numerical model experiment was set up to reproduce the spatial distribution of specific particle pollutants, from the regional scales and the interactions between different cities, to the local scales with specific turbulent structures. Observations show that local dynamics depends on the day-regime, and may lead to different mesoscale dynamical structures. This study focuses on reproducing these fine scale dynamical structures, and investigate the impact on the aerosol plume dispersion. The 500-m resolution simulation manages to reproduce convective rolls at local scale, which concentrate most of the aerosol particles and can locally affect the pollutant dispersion and air quality

Scavenging of aerosol particles by rain in a cloud resolving model

International audienceWe describe a below-cloud scavenging module of aerosol particles by raindrops for use in a three-dimensional mesoscale cloud resolving model. The rate of particle removal is computed by integrating the scavenging efficiency over the aerosol particle and the drop size distributions. Here the numerical integration is performed accurately with a Gauss quadrature algorithm. The efficiency of the scavenging module is partially confirmed with experimental data. More interestingly, it is illustrated by two numerical experiments: the simulation of a forced convective circulation in a tropical cloudy boundary layer and a two-dimensional simulation of an African squall line. The results show a very selective wet removal of the aerosol particles which clearly depends on the mode radius, the width and the vertical profile of concentration. Furthermore, the squall line case shows the importance of resolving internal circulations to redistribute layers of aerosol particles in order to improve estimates of particle removal by below-cloud scavenging

Comment on "Linear wave dynamics explains observations attributed to dark-solitons in a polariton quantum fluid"

In a recent preprint (arXiv:1401.1128v1) Cilibrizzi and co-workers report experiments and simulations showing the scattering of polaritons against a localised obstacle in a semiconductor microcavity. The authors observe in the linear excitation regime the formation of density and phase patterns reminiscent of those expected in the non-linear regime from the nucleation of dark solitons. Based on this observation, they conclude that previous theoretical and experimental reports on dark solitons in a polariton system should be revised. Here we comment why the results from Cilibrizzi et al. take place in a very different regime than previous investigations on dark soliton nucleation and do not reproduce all the signatures of its rich nonlinear phenomenology. First of all, Cilibrizzi et al. consider a particular type of radial excitation that strongly determines the observed patterns, while in previous reports the excitation has a plane-wave profile. Most importantly, the nonlinear relation between phase jump, soliton width and fluid velocity, and the existence of a critical velocity with the time-dependent formation of vortex-antivortex pairs are absent in the linear regime. In previous reports about dark soliton and half-dark soliton nucleation in a polariton fluid, the distinctive dark soliton physics is supported both by theory (analytical and numerical) and experiments (both continuous wave and pulsed excitation).Comment: 4 pages, 2 figure

Development and evaluation of a building energy model integrated in the TEB scheme

The use of air-conditioning systems is expected to increase as a consequence of global-scale and urban-scale climate warming. In order to represent future scenarios of urban climate and building energy consumption, the Town Energy Balance (TEB) scheme must be improved. This paper presents a new building energy model (BEM) that has been integrated in the TEB scheme. BEM-TEB makes it possible to represent the energy effects of buildings and building systems on the urban climate and to estimate the building energy consumption at city scale (~10 km) with a resolution of a neighbourhood (~100 m). The physical and geometric definition of buildings in BEM has been intentionally kept as simple as possible, while maintaining the required features of a comprehensive building energy model. The model considers a single thermal zone, where the thermal inertia of building materials associated with multiple levels is represented by a generic thermal mass. The model accounts for heat gains due to transmitted solar radiation, heat conduction through the enclosure, infiltration, ventilation, and internal heat gains. BEM allows for previously unavailable sophistication in the modelling of air-conditioning systems. It accounts for the dependence of the system capacity and efficiency on indoor and outdoor air temperatures and solves the dehumidification of the air passing through the system. Furthermore, BEM includes specific models for passive systems, such as window shadowing devices and natural ventilation. BEM has satisfactorily passed different evaluation processes, including testing its modelling assumptions, verifying that the chosen equations are solved correctly, and validating the model with field data.French National Research Agency (ANR). MUSCADE project (ANR-09-VILL-003)European Commission Framework Program (FP7/2007–2013) (BRIDGE Project grant 211345

Tamoxifen-like metallocifens target thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells

Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved in cellular redox balance, is often overexpressed in cancer cells, especially in tumour types resistant to standard chemotherapies. Therefore, we investigated the effect of these three TLMs on the thioredoxin system and evaluated the input of the metallocene unit in comparison with structurally related organic tamoxifens. In vitro, all three TLMs became strong inhibitors of the cytosolic (TrxR1) and mitochondrial (TrxR2) isoforms of thioredoxin reductase after enzymatic oxidation with HRP/H2O2 while none of the organic analogues was effective. In Jurkat cells, TLMs inhibited mainly TrxR2, resulting in the accumulation of oxidized thioredoxin 2 and cell redox imbalance. Overproduction of ROS resulted in a strong decrease in the mitochondrial membrane potential, translocation of cytochrome c to the cytosol and activation of caspase 3, thus leading to apoptosis. None of these events occurred with organic tamoxifens. The mitochondrial fraction of cells exposed to TLMs contained a high amount of the corresponding metal, as quantified by ICP-OES. The lipophilic and cationic character associated with the singular redox properties of the TLMs could explain why they alter the mitochondrial function. These results provide new insights into the mechanism of action of tamoxifen-like metallocifens, underlying their prodrug behaviour and the pivotal role played by the metallocenic entity in their cytotoxic activity associated with the induction of apoptosis

Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model

Ferrociphenol (Fc-diOH) is a new molecule belonging to the fast-growing family of organometallic anti-cancer drugs. In a previous study, we showed promising in vivo results obtained after the intratumoural subcutaneous administration of the new drug-carrier system Fc-diOH-LNCs on a 9L-glioma model. To further increase the dose of this lipophilic entity, we have created a series of prodrugs of Fc-diOH. The phenol groups were protected by either an acetyl (Fc-diAc) or by the long fatty-acid chain of a palmitate (Fc-diPal). LNCs loaded with Fc-diOH prodrugs have to be activated in situ by enzymatic hydrolysis. We show here that the protection of diphenol groups with palmitoyl results in the loss of Fc-diOH in vitro activity, probably due to a lack of in situ hydrolysis. On the contrary, protection with an acetate group does not affect the strong, in vitro, antiproliferative effect of ferrocifen-loaded-LNCs neither the reduction of tumour volume observed on an ectopic model, confirming that acetate is easily cleaved by cell hydrolases. Moreover, the cytostatic activity of Fc-diOH-LNCs is confirmed on an orthotopic glioma model since the difference in survival time between the infusion of 0.36 mg/rat Fc-diOH-LNCs and blank LNCs is statistically significant. By using LNCs or Labrafac to carry the drug, a dose-effect ranging from 0.005 to 2.5mg of Fc-diOH per animal can be evidenced

Programmable and arbitrary-trajectory ultrafast flying focus pulses

"Flying focus" techniques produce laser pulses with dynamic focal points that travels distances much greater than a Rayleigh length. The implementation of these techniques in laser-based applications requires the design of optical configurations that can both extend the focal range and structure the radial group delay. This article describes a method for designing optical configurations that produce ultrashort flying focus pulses with arbitrary-trajectory focal points. The method is illustrated by several examples that employ an axiparabola for extending the focal range and either a reflective echelon or a deformable mirror-spatial light modulator pair for structuring the radial group delay. The latter configuration enables rapid exploration and optimization of flying foci, which could be ideal for experiments

Spatiotemporal control of two-color terahertz generation

A laser pulse composed of a fundamental and properly phased second harmonic exhibits an asymmetric electric field that can drive a time-dependent current of photoionized electrons. The current produces an ultrashort burst of terahertz (THz) radiation. When driven by a conventional laser pulse, the THz radiation is emitted into a cone with an angle determined by the dispersion of the medium. Here we demonstrate that the programmable-velocity intensity peak of a spatiotemporally structured, two-color laser pulse can be used to control the emission angle, focal spot, and spectrum of the THz radiation. Of particular interest for applications, a structured pulse with a subluminal intensity peak can drive highly focusable, on-axis THz radiation